Norepinephrine Dosage Is Associated With Lactate Clearance After Resuscitation in Patients With Septic Shock.

ABSTRACT: Background: Some septic shock patients have persistent hyperlactacidemia despite a normal systemic hemodynamics after resuscitation. Central venous oxygen saturation (ScvO₂), mean arterial pressure (MAP), and central venous pressure (CVP) cannot be target in subsequent hemodynamic treatments. Vasoplegia is considered to be one of the main causes of oxygen metabolism abnormalities in septic shock patients, and norepinephrine (NE) is the first-line vasopressor in septic shock treatment; its dosage represents the severity of vasoplegia. This study was performed to determine whether vasoplegia, as assessed by NE dosage, can indicate patients' lactate clearance after the completion of resuscitation. Methods: A retrospective study was performed, and 106 patients with sep

SUBMITTER: Yu C 

PROVIDER: S-EPMC8688855 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature