High Altitude Pregnancies and Vascular Dysfunction: Observations From Latin American Studies.

ABSTRACT: An estimated human population of 170 million inhabit at high-altitude (HA, above 2,500 m). The potential pathological effects of HA hypobaric hypoxia during gestation have been the focus of several researchers around the world. The studies based on the Himalayan and Central/South American mountains are particularly interesting as these areas account for nearly 70% of the HA world population. At present, studies in human and animal models revealed important alterations in fetal development and growth at HA. Moreover, vascular responses to chronic hypobaria in the pregnant mother and her fetus may induce marked cardiovascular impairments during pregnancy or in the neonatal period. In addition, recent studies have shown potential long-lasting postnatal effects that may increase cardiovascular

SUBMITTER: Gonzalez-Candia A 

PROVIDER: S-EPMC8688922 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature