Gene-Based Therapeutics for Acquired Retinal Disease: Opportunities and Progress.

ABSTRACT: Acquired retinal diseases such as age-related macular degeneration and diabetic retinopathy rank among the leading causes of blindness and visual loss worldwide. Effective treatments for these conditions are available, but often have a high treatment burden, and poor compliance can lead to disappointing real-world outcomes. Development of new treatment strategies that provide more durable treatment effects could help to address some of these unmet needs. Gene-based therapeutics, pioneered for the treatment of monogenic inherited retinal disease, are being actively investigated as new treatments for acquired retinal disease. There are significant advantages to the application of gene-based therapeutics in acquired retinal disease, including the presence of established therapeutic targets an

SUBMITTER: Tan TE 

PROVIDER: S-EPMC8688942 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature