Current status of neuroprotective and neuroregenerative strategies in multiple sclerosis: A systematic review.

ABSTRACT:

Background

Immune-mediated demyelination and consequent degeneration of oligodendrocytes and axons are hallmark features of multiple sclerosis (MS). Remyelination declines in progressive MS, causing permanent axonal loss and irreversible disabilities. Strategies aimed at enhancing remyelination are critical to attenuate disease progression.

Objective

We systematically reviewed recent advances in neuroprotective and regenerative therapies for MS, covering preclinical and clinical studies.

Methods

We searched three biomedical databases using defined keywords. Two authors independently reviewed articles for inclusion based on pre-specified criteria. The data were extracted from each study and assessed for risk of bias.

Results

Our search identified 7351 studies fr

SUBMITTER: Allanach JR 

PROVIDER: S-EPMC8688986 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature