M6A Regulators in Human Adipose Tissue - Depot-Specificity and Correlation With Obesity.

ABSTRACT:

Background

N⁶-methyladenosine (m6A) is one of the most abundant post-transcriptional modifications on mRNA influencing mRNA metabolism. There is emerging evidence for its implication in metabolic disease. No comprehensive analyses on gene expression of m6A regulators in human adipose tissue, especially in paired adipose tissue depots, and its correlation with clinical variables were reported so far. We hypothesized that inter-depot specific gene expression of m6A regulators may differentially correlate with clinical variables related to obesity and fat distribution.

Methods

We extracted intra-individually paired gene expression data (omental visceral adipose tissue (OVAT) N=48; subcutaneous adipose tissue (SAT) N=56) of m6A regulators from an existin

SUBMITTER: Ronningen T 

PROVIDER: S-EPMC8689137 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature