Heterosynaptic Plasticity and the Experience-Dependent Refinement of Developing Neuronal Circuits.

ABSTRACT: Neurons remodel the structure and strength of their synapses during critical periods of development in order to optimize both perception and cognition. Many of these developmental synaptic changes are thought to occur through synapse-specific homosynaptic forms of experience-dependent plasticity. However, homosynaptic plasticity can also induce or contribute to the plasticity of neighboring synapses through heterosynaptic interactions. Decades of research in vitro have uncovered many of the molecular mechanisms of heterosynaptic plasticity that mediate local compensation for homosynaptic plasticity, facilitation of further bouts of plasticity in nearby synapses, and cooperative induction of plasticity by neighboring synapses acting in concert. These discoveries greatly benefited fro

SUBMITTER: Jenks KR 

PROVIDER: S-EPMC8689143 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature