Association between dementia parental family history and mid-life modifiable risk factors for dementia: a cross-sectional study using propensity score matching within the Lifelines cohort.

ABSTRACT:

Objective

Individuals with a parental family history (PFH) of dementia have an increased risk to develop dementia, regardless of genetic risks. The aim of this study is to investigate the association between a PFH of dementia and currently known modifiable risk factors for dementia among middle-aged individuals using propensity score matching (PSM).

Design

A cross-sectional study.

Setting and participants

A subsample of Lifelines (35-65 years), a prospective population-based cohort study in the Netherlands was used.

Outcome measures

Fourteen modifiable risk factors for dementia and the overall Lifestyle for Brain Health (LIBRA) score, indicating someone's potential for dementia risk reduction (DRR).

Results

The study population included 89 869 participan

SUBMITTER: Vrijsen J 

PROVIDER: S-EPMC8689157 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature