Automated Design of Robust Genetic Circuits: Structural Variants and Parameter Uncertainty.

ABSTRACT: Genetic design automation methods for combinational circuits often rely on standard algorithms from electronic design automation in their circuit synthesis and technology mapping. However, those algorithms are domain-specific and are hence often not directly suitable for the biological context. In this work we identify aspects of those algorithms that require domain-adaptation. We first demonstrate that enumerating structural variants for a given Boolean specification allows us to find better performing circuits and that stochastic gate assignment methods need to be properly adjusted in order to find the best assignment. Second, we present a general circuit scoring scheme that accounts for the limited accuracy of biological device models including the variability across cells and show that

SUBMITTER: Schladt T 

PROVIDER: S-EPMC8689692 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature