Accelerating Whole-Cell Simulations of mRNA Translation Using a Dedicated Hardware.

ABSTRACT: In recent years, intracellular biophysical simulations have been used with increasing frequency not only for answering basic scientific questions but also in the field of synthetic biology. However, since these models include networks of interaction between millions of components, they are extremely time-consuming and cannot run easily on parallel computers. In this study, we demonstrate for the first time a novel approach addressing this challenge by using a dedicated hardware designed specifically to simulate such processes. As a proof of concept, we specifically focus on mRNA translation, which is the process consuming most of the energy in the cell. We design a hardware that simulates translation in Escherichia coli and Saccharomyces cerevisiae for thousands of mRNAs and

SUBMITTER: Shallom D 

PROVIDER: S-EPMC8689694 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature