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SARS-CoV-2 mRNA Vaccines in Allogeneic Hematopoietic Stem Cell Transplant Recipients: Immunogenicity and Reactogenicity.

ABSTRACT: The SARS-CoV-2 mRNA vaccine-induced humoral response and reactogenicity profile are described in allogeneic hematopoietic stem cell transplant (HSCT) recipients. 75.0% (by Simoa assay) or 80.0% (by Roche assay) of the HSCT cohort had a positive antibody response upon series completion, as compared to 100% in the healthy cohort.

SUBMITTER: Sherman AC

PROVIDER: S-EPMC8689898 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccines in Allogeneic Hematopoietic Stem Cell Transplant Recipients: Immunogenicity and Reactogenicity.

Sherman Amy C AC Desjardins Michaël M Cheng Chi An CA Bausk Bruce B Izaguirre Natalie N Zhou Guohai G Krauss Jonathan J Tolan Nicole N Walt David R DR Soiffer Robert R Ho Vincent T VT Issa Nicolas C NC Baden Lindsey R LR

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20220801 1

The severe acute respiratory syndrome coronavirus 2 messenger RNA vaccine-induced humoral response and reactogenicity profile are described in allogeneic hematopoietic stem cell transplant (HSCT) recipients. Findings showed that 75.0% (by Simoa assay) or 80.0% (by Roche assay) of the HSCT cohort had a positive antibody response on series completion, compared with 100% in the healthy cohort. ...[more]

PMID: 34726754

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