Ontology highlight
ABSTRACT:
SUBMITTER: Jacobs TG
PROVIDER: S-EPMC8690014 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Jacobs Tom G TG Marzolini Catia C Back David J DJ Burger David M DM
The Journal of antimicrobial chemotherapy 20220201 3
Global use of dexamethasone in COVID-19 patients has revealed a poor understanding of the drug-drug interaction (DDI) potential of dexamethasone, particularly with antiretroviral agents (ARVs). Dexamethasone is both a substrate and a dose-dependent inducer of cytochrome P450 3A4 (CYP3A4). As many ARVs are substrates and/or inhibitors or inducers of CYP3A4, there is concern about DDIs with dexamethasone either as a perpetrator or a victim. Assessment of DDIs that involve dexamethasone is complex ...[more]