Renal diseases secondary to interferon-β treatment: a multicentre clinico-pathological study and systematic literature review.

ABSTRACT:

Background

The spectrum of interferon-β (IFN-β)-associated nephropathy remains poorly described and the potential features of this uncommon association remain to be determined.

Methods

In this study we retrospectively analysed the clinical, laboratory, histological and therapeutic data of patients with biopsy-proven renal disease in a context of IFN-β treatment administered for at least 6 months.

Results

Eighteen patients (13 women, median age 48 years) with biopsy-proven renal disease occurring during IFN-β therapy were included. The median exposure to IFN-β (14 patients were treated with IFN-β1a and 4 patients with IFN-β1b) was 67 months (range 23-165 months). The clinical presentation consists in hypertension (HT; 83%), malignant HT (44%), proteinuria (protU) >1 g/

SUBMITTER: Dauvergne M 

PROVIDER: S-EPMC8690152 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature