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Simple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes.

ABSTRACT: Simple primary β-amino alcohols act as an efficient organocatalysts in the asymmetric Michael addition of β-keto esters with nitroalkenes affording highly pure chiral Michael adducts. Also, both enantiomers of the adducts were obtained, depending on the specific catalyst used and reaction temperature.

SUBMITTER: Begum Z

PROVIDER: S-EPMC8690173 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Simple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes.

Begum Zubeda Z Sannabe Haruka H Seki Chigusa C Okuyama Yuko Y Kwon Eunsang E Uwai Koji K Tokiwa Michio M Tokiwa Suguru S Takeshita Mitsuhiro M Nakano Hiroto H

RSC advances 20201222 1

Simple primary β-amino alcohols act as an efficient organocatalysts in the asymmetric Michael addition of β-keto esters with nitroalkenes affording highly pure chiral Michael adducts. Also, both enantiomers of the adducts were obtained, depending on the specific catalyst used and reaction temperature. ...[more]

PMID: 35423042

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