Impact of multisession 40Hz tACS on hippocampal perfusion in patients with Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is associated with alterations in cortical perfusion that correlate with cognitive impairment. Recently, neural activity in the gamma band has been identified as a driver of arteriolar vasomotion while, on the other hand, gamma activity induction on preclinical models of AD has been shown to promote protein clearance and cognitive protection.

Methods

In two open-label studies, we assessed the possibility to modulate cerebral perfusion in 15 mild to moderate AD participants via 40Hz (gamma) transcranial alternating current stimulation (tACS) administered 1 h daily for 2 or 4 weeks, primarily targeting the temporal lobe. Perfusion-sensitive MRI scans were acquired at baseline and right after the intervention, along with electrophysiological

SUBMITTER: Sprugnoli G 

PROVIDER: S-EPMC8690894 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature