A hydrogen peroxide economizer for on-demand oxygen production-assisted robust sonodynamic immunotherapy.

ABSTRACT: The outcome of sonodynamic immunotherapy is significantly limited by tumor hypoxia. To overcome this obstacle, one common solution is to catalyze the conversion of endogenous H₂O₂ into O₂. However, the effectiveness of this strategy is limited by the insufficient concentration of H₂O₂ in the tumor microenvironment (TME). Herein, we developed a H₂O₂ economizer for on-demand O₂ supply and sonosensitizer-mediated reactive oxygen species production during ultrasound activation, thereby alleviating hypoxia-associated limitations and augmenting the efficacy of sonodynamic immunotherapy. Methods: The H₂O₂ economizer is constructed by electrostatic adsorption and π-π interactions be

SUBMITTER: Jiang Q 

PROVIDER: S-EPMC8690934 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature