Anti-vascular endothelial growth factor therapy for age-related macular degeneration: a systematic review and network meta-analysis.

ABSTRACT:

Background

The comparative safety and efficacy between anti-vascular endothelial growth factor agents (anti-VEGFs) and between combined therapies for patients with neovascular age-related macular degeneration (nAMD) is unclear. We conducted a systematic review to examine the comparative safety and efficacy anti-VEGFs for adults with nAMD.

Methods

Studies were identified through MEDLINE, EMBASE, and Cochrane CENTRAL (inception to June 3, 2019), grey literature, and scanning reference lists. Two reviewers independently screened citations and full-text articles to identify randomized controlled trials (RCTs), extracted data, and appraised risk of bias. Pairwise random-effects meta-analysis and Bayesian network meta-analysis (NMA) were conducted. The primary outcomes were the pr

SUBMITTER: Tricco AC 

PROVIDER: S-EPMC8690960 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature