Implication of proliferation gene biomarkers in pulmonary hypertension.

ABSTRACT:

Objective/background

Proliferation is a widely recognized trigger for pulmonary hypertension (PH), a life-threatening, progressive disorder of pulmonary blood vessels. This study was aimed to identify some proliferation associated genes/targets for better comprehension of PH pathogenesis.

Methods

Human pulmonary arterial smooth muscle cells (hPASMCs) were cultured in the presence or absence of human recombinant platelet derived growth factor (rhPDGF)-BB. Cells were collected for metabolomics or transcriptomics study. Gene profiling of lungs of PH rats after hypoxia exposure or of PH patients were retrieved from GEO database.

Results

90 metabolites (VIP score >1, fold change >2 or <0.5 and p < .05) and 2701 unique metabolism associated genes (MAGs) were identifi

SUBMITTER: Yan Y 

PROVIDER: S-EPMC8690983 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature