Aptamer Sandwich Assay for the Detection of SARS-CoV-2 Spike Protein Antigen.

ABSTRACT: The novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) emerged at the end of 2019, resulting in the ongoing COVID-19 pandemic. The high transmissibility of the virus and the substantial number of asymptomatic individuals have led to an exponential rise in infections worldwide, urgently requiring global containment strategies. Reverse transcription-polymerase chain reaction is the gold standard for the detection of SARS-CoV-2 infections. Antigen tests, targeting the spike (S) or nucleocapsid (N) viral proteins, are considered as complementary tools. Despite their shortcomings in terms of sensitivity and specificity, antigen tests could be deployed for the detection of potentially contagious individuals with high viral loads. In this work, we sought to develop a sandwich aptame

SUBMITTER: Svobodova M 

PROVIDER: S-EPMC8691202 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature