Variability of the Plasma Lipidome and Subclinical Coronary Atherosclerosis.

ABSTRACT:

Objective

While the risk of acute coronary events has been associated with biological variability of circulating cholesterol, the association with variability of other atherogenic lipids remains less understood. We evaluated the longitudinal variability of 284 lipids and investigated their association with asymptomatic coronary atherosclerosis. Approach and Results: Circulating lipids were extracted from fasting blood samples of 83 community-sampled symptom-free participants (age 41-75 years), collected longitudinally over 6 months. Three types of coronary plaque volume (calcified, lipid-rich, and fibrotic) were quantified using computed tomography coronary angiogram. We first deconvoluted between-subject (CV_g) and within-subject (CV_w) lipid variabilities. We

SUBMITTER: Tan SH 

PROVIDER: S-EPMC8691371 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature