Commensal-driven immune zonation of the liver promotes host defence.

ABSTRACT: The liver connects the intestinal portal vasculature with the general circulation, using a diverse array of immune cells to protect from pathogens that translocate from the gut¹. In liver lobules, blood flows from portal triads that are situated in periportal lobular regions to the central vein via a polarized sinusoidal network. Despite this asymmetry, resident immune cells in the liver are considered to be broadly dispersed across the lobule. This differs from lymphoid organs, in which immune cells adopt spatially biased positions to promote effective host defence^2,3. Here we used quantitative multiplex imaging, genetic perturbations, transcriptomics, infection-based assays and mathematical modelling to reassess the relationship between the localization of immune ce

SUBMITTER: Gola A 

PROVIDER: S-EPMC8691525 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature