Long-term viability and extensibility of an in situ regenerated canine aortic wall using hybrid warp-knitted fabric.

ABSTRACT:

Objectives

Many surgical materials promoting tissue regeneration have been explored for use in paediatric cardiac surgery. The aim of this study is to evaluate the long-term viability and extensibility of the canine aortic wall regenerated using a novel synthetic hybrid fabric.

Methods

The sheet is a warp-knitted fabric of biodegradable (poly-l-lactic acid) and non-biodegradable (polyethylene terephthalate) yarns coated with cross-linked gelatine. This material was implanted as a patch to fill an oval-shaped defect created in the canine descending aorta. The tissue samples were explanted after 12, 24 or 36 months (N = 3, 2, 2, respectively) for histological examination and biomechanical testing.

Results

There was no shrinkage, rupture or aneurysmal change after 24 mon

SUBMITTER: Nemoto S 

PROVIDER: S-EPMC8691562 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature