Prognostic value of comprehensive intracoronary physiology assessment early after heart transplantation.

ABSTRACT:

Aims

We evaluated the long-term prognostic value of invasively assessing coronary physiology after heart transplantation in a large multicentre registry.

Methods and results

Comprehensive intracoronary physiology assessment measuring fractional flow reserve (FFR), the index of microcirculatory resistance (IMR), and coronary flow reserve (CFR) was performed in 254 patients at baseline (a median of 7.2 weeks) and in 240 patients at 1 year after transplantation (199 patients had both baseline and 1-year measurement). Patients were classified into those with normal physiology, reduced FFR (FFR ≤ 0.80), and microvascular dysfunction (either IMR ≥ 25 or CFR ≤ 2.0 with FFR > 0.80). The primary outcome was the composite of death or re-transplantation at 10 years. At baseline, 5.5% h

SUBMITTER: Ahn JM 

PROVIDER: S-EPMC8691805 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature