Developing a morphomics framework to optimize implant site-specific design parameters for islet macroencapsulation devices.

ABSTRACT: Delivering a clinically impactful cell number is a major design challenge for cell macroencapsulation devices for Type 1 diabetes. It is important to understand the transplant site anatomy to design a device that is practical and that can achieve a sufficient cell dose. We identify the posterior rectus sheath plane as a potential implant site as it is easily accessible, can facilitate longitudinal monitoring of transplants, and can provide nutritive support for cell survival. We have investigated this space using morphomics across a representative patient cohort (642 participants) and have analysed the data in terms of gender, age and BMI. We used a shape optimization process to maximize the volume and identified that elliptical devices achieve a clinically impactful cell dose while meetin

SUBMITTER: McDermott B 

PROVIDER: S-EPMC8692035 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature