Dynamic Protein Corona of Gold Nanoparticles with an Evolving Morphology.

ABSTRACT: Much has been learned about the protein coronae and their biological implications within the context of nanomedicine and nanotoxicology. However, no data is available about the protein coronae associated with nanoparticles undergoing spontaneous surface-energy minimization, a common phenomenon during the synthesis and shelf life of nanomaterials. Accordingly, here we employed gold nanoparticles (AuNPs) possessing the three initial states of spiky, midspiky, and spherical shapes and determined their acquisition of human plasma protein coronae with label-free mass spectrometry. The AuNPs collected coronal proteins that were different in abundance, physicochemical parameters, and interactive biological network. The size and structure of the coronal proteins matched the morphology of the AuNPs

SUBMITTER: Nandakumar A 

PROVIDER: S-EPMC8692073 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature