Ontology highlight
ABSTRACT:
SUBMITTER: Zeng M
PROVIDER: S-EPMC8692121 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Zeng Mei M Li Qingxiang Q Chen Junzhao J Huang Wenfu W Liu Jinhua J Wang Cuiyan C Huang Manni M Li Hui H Zhou Shu S Xie Miaoying M Zeng Kang K
International journal of medical sciences 20220101 1
Human fibroleukin 2 (Fgl2), a member of the fibrinogen superfamily, can cleave prothrombin to generate thrombin or is secreted in a soluble form as a new type of effector of Tregs with immunomodulatory functions. However, there is little research on the role of Fgl2 in cutaneous squamous cell carcinoma (CSCC) growth. We examined the expression of Fgl2 in samples from CSCC patients and CSCC cell lines. Then, the effect of Fgl2 on CSCC was evaluated <i>in vitro</i> and in animals. Regulation of au ...[more]