Serum IL-27 predicts the severity and prognosis in patients with community-acquired pneumonia: a prospective cohort study.

ABSTRACT: Background: The previous studies have revealed that IL-27 was involved in the pathophysiology of pulmonary inflammatory diseases. However, the role of IL-27 in community-acquired pneumonia (CAP) was unclear. The goal of this research was to explore the associations of serum IL-27 with the severity and prognosis among CAP patients through a prospective cohort study. Methods: The whole of 239 healthy population and 239 CAP patients were enrolled. Fasting blood samples were collected. Inflammatory cytokines were detected using enzyme linked immunosorbent assay (ELISA). Demographic characteristics and clinical information were analyzed. Results: Serum IL-27 on admission was significantly risen in CAP patients compared with control subjects. Besides, serum IL-27 was gradual

SUBMITTER: Xu Z 

PROVIDER: S-EPMC8692123 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature