Neuronal current imaging: An experimental method to investigate electrical currents in dogs with idiopathic epilepsy.

ABSTRACT:

Background

The diagnosis of idiopathic epilepsy (IE) in dogs is based on exclusion of other potential causes of seizures. Recently, a novel magnetic resonance imaging (MRI) sequence that utilizes a variant of the rotary saturation approach has been suggested to detect weak transient magnetic field oscillations generated by neuronal currents in humans with epilepsy.

Hypothesis/objectives

Effects on the magnetic field evoked by intrinsic epileptic activity can be detected by MRI in the canine brain. As proof-of-concept, the novel MRI sequence to detect neuronal currents was applied in dogs.

Animals

Twelve dogs with IE and 5 control dogs without a history of epileptic seizures were examined.

Methods

Prospective case-control study as proof-of-concept. All dogs unde

SUBMITTER: Unger DM 

PROVIDER: S-EPMC8692176 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature