Histopathologic, phenotypic, and molecular criteria to discriminate low-grade intestinal T-cell lymphoma in cats from lymphoplasmacytic enteritis.

ABSTRACT:

Background

Differentiation of low-grade intestinal T-cell lymphoma (LGITL) from lymphoplasmacytic enteritis (LPE) in cats is a diagnostic challenge for pathologists.

Objective

Characterize histologic, immunohistochemical, and molecular features of LGITL and LPE.

Animals

Forty-four client-owned cats, 22 diagnosed with LGITL and 22 with LPE.

Methods

Prospective, cohort study. Clinical suspicion of LGITL or LPE was based on persistent gastrointestinal signs, unresponsive to empirical treatments. All cats underwent a standardized diagnostic evaluation, including biopsy (preferentially full-thickness), and were diagnosed with LGITL or LPE after review of clinical, laboratory, sonographic, histologic, immunohistochemical, and clonality results.

Results

A monom

SUBMITTER: Freiche V 

PROVIDER: S-EPMC8692189 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature