Randomized, controlled trial comparing Rhodococcus equi and poly-N-acetyl glucosamine hyperimmune plasma to prevent R equi pneumonia in foals.

ABSTRACT:

Background

Hyperimmune plasma raised against β-1→6-poly-N-acetyl glucosamine (PNAG HIP) mediates more opsonophagocytic killing of Rhodococcus equi (R equi) than does R equi hyperimmune plasma (RE HIP) in vitro. The relative efficacy of PNAG HIP and RE HIP to protect foals against R equi pneumonia, however, has not been evaluated.

Hypothesis

Transfusion with PNAG HIP will be superior to RE HIP in foals for protection against R equi pneumonia in a randomized, controlled, blinded clinical trial.

Animals

Four hundred sixty Quarter Horse and Thoroughbred foals at 5 large breeding farms in the United States.

Methods

A randomized, controlled, blinded clinical trial was conducted in which foals were transfused within 24 hours after birth with 2 L of either RE HIP or PN

SUBMITTER: Kahn SK 

PROVIDER: S-EPMC8692225 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature