Isoflurane in (Super-) Refractory Status Epilepticus: A Multicenter Evaluation.

ABSTRACT:

Background

We aimed to determine the association between seizure termination and side effects of isoflurane for the treatment of refractory status epilepticus (RSE) and super-refractory status epilepticus (SRSE) in neurointensive care units (neuro-ICUs).

Methods

This was a multicenter retrospective study of patients with RSE/SRSE treated with isoflurane for status epilepticus termination admitted to the neuro-ICUs of nine German university centers during 2011-2018.

Results

We identified 45 patients who received isoflurane for the treatment of RSE/SRSE. During isoflurane treatment, electroencephalograms showed no epileptiform discharges in 33 of 41 (80%) patients, and burst suppression pattern was achieved in 29 of 41 patients (71%). RSE/SRSE was finally terminated aft

SUBMITTER: Stetefeld HR 

PROVIDER: S-EPMC8692280 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature