Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults.

ABSTRACT:

Background

suPAR (Soluble urokinase plasminogen activator receptor) has emerged as an important biomarker of coagulation, inflammation, and cardiovascular disease (CVD) risk. The contribution of suPAR to CVD risk and its genetic influence in Black populations have not been evaluated.

Methods

We measured suPAR in 3492 Black adults from the prospective, community-based JHS (Jackson Heart Study). Cross-sectional associations of suPAR with lifestyle and CVD risk factors were assessed, whole-genome sequence data were used to evaluate genetic associations of suPAR, and relationships of suPAR with incident CVD outcomes and overall mortality were estimated over follow-up.

Results

In Cox models adjusted for traditional CVD risk factors, estimated glomerular filtration rate, an

SUBMITTER: Olson NC 

PROVIDER: S-EPMC8692389 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature