Rho and F-actin self-organize within an artificial cell cortex.

ABSTRACT: The cell cortex, comprised of the plasma membrane and underlying cytoskeleton, undergoes dynamic reorganizations during a variety of essential biological processes including cell adhesion, cell migration, and cell division.^1,2 During cell division and cell locomotion, for example, waves of filamentous-actin (F-actin) assembly and disassembly develop in the cell cortex in a process termed "cortical excitability."^3-7 In developing frog and starfish embryos, cortical excitability is generated through coupled positive and negative feedback, with rapid activation of Rho-mediated F-actin assembly followed in space and time by F-actin-dependent inhibition of Rho.^7,8 These feedback loops are proposed to serve as a mechani

SUBMITTER: Landino J 

PROVIDER: S-EPMC8692417 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature