Polarized Dishevelled dissolution and reassembly drives embryonic axis specification in sea star oocytes.

ABSTRACT: The organismal body axes that are formed during embryogenesis are intimately linked to intrinsic asymmetries established at the cellular scale in oocytes.¹ However, the mechanisms that generate cellular asymmetries within the oocyte and then transduce that polarity to organismal scale body axes are poorly understood outside of select model organisms. Here, we report an axis-defining event in meiotic oocytes of the sea star Patiria miniata. Dishevelled (Dvl) is a cytoplasmic Wnt pathway effector required for axis development in diverse species,^2-4 but the mechanisms governing its function and distribution remain poorly defined. Using time-lapse imaging, we find that Dvl localizes uniformly to puncta throughout the cell cortex in Prophase I-arrested oocytes but becomes

SUBMITTER: Swartz SZ 

PROVIDER: S-EPMC8692449 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature