Machine learning prediction of antiviral-HPV protein interactions for anti-HPV pharmacotherapy.

ABSTRACT: Persistent infection with high-risk types Human Papillomavirus could cause diseases including cervical cancers and oropharyngeal cancers. Nonetheless, so far there is no effective pharmacotherapy for treating the infection from high-risk HPV types, and hence it remains to be a severe threat to the health of female. Based on drug repositioning strategy, we trained and benchmarked multiple machine learning models so as to predict potential effective antiviral drugs for HPV infection in this work. Through optimizing models, measuring models' predictive performance using 182 pairs of antiviral-target interaction dataset which were all approved by the United States Food and Drug Administration, and benchmarking different models' predictive performance, we identified the optimized Support Vector

SUBMITTER: Lin HH 

PROVIDER: S-EPMC8692573 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature