Long noncoding RNA Meg3 sponges miR-708 to inhibit intestinal tumorigenesis via SOCS3-repressed cancer stem cells growth.

ABSTRACT:

Background

Colorectal cancer (CRC) remains the most common gastrointestinal cancer and a leading cause of cancer deaths worldwide, with most showing pathologies indicating the malignant transformation of early stage intestinal stem cells. The long non-coding RNA Meg3, which functions as a tumor suppressor, has been reported to be abnormal in multiple tumorigenesis events; however, the underlying mechanism by which Meg3 contributes to the malignant proliferation of colonic stem cells remains unclear.

Methods

We analyzed the expression levels of Meg3, miR-708, and SOCS3 in samples from Apc loss-of-function (Apc^min) mice and patients with CRC, particularly in colonic crypt cells. Apc^min mice and AMO/DSS-induced mice model (in vivo) and organoid culture sys

SUBMITTER: Zhang S 

PROVIDER: S-EPMC8692598 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature