Carbon nano-dot for cancer studies as dual nano-sensor for imaging intracellular temperature or pH variation.

ABSTRACT: Cellular temperature and pH govern many cellular physiologies, especially of cancer cells. Besides, attaining higher cellular temperature plays key role in therapeutic efficacy of hyperthermia treatment of cancer. This requires bio-compatible, non-toxic and sensitive probe with dual sensing ability to detect temperature and pH variations. In this regard, fluorescence based nano-sensors for cancer studies play an important role. Therefore, a facile green synthesis of orange carbon nano-dots (CND) with high quantum yield of 90% was achieved and its application as dual nano-sensor for imaging intracellular temperature and pH was explored. CND was synthesized from readily available, bio-compatible citric acid and rhodamine 6G hydrazide using solvent-free and simple heating technique requiring

SUBMITTER: Gadly T 

PROVIDER: S-EPMC8692618 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature