Toxicity evaluation in rats following 28 days of inhalation exposure to xylitol aerosol.

ABSTRACT: Xylitol has reported to decrease gingival inflammation and nasopharyngeal pneumonia, which indicated that xylitol may have potential application in respiratory diseases. Although some studies have reported the inhalation toxicity of xylitol, however, the longest period tested was only for 14 days. The inhalation toxicity of xylitol is insufficient. This work investigated the potential subacute toxicity of xylitol according to the OECD TG 412. Rats were randomly divided into a control group and different dosage groups (2 g/m³, 3 g/m³, 5 g/m³), and exposed for 6 hours/day, 5 days/week for 28 days. At the end of the exposure or recovery period, clinical signs, mortality, body weight, food consumption, hematology, blood biochemistry, gross pathology, organ weig

SUBMITTER: Tian Y 

PROVIDER: S-EPMC8692747 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature