Dysregulation of interaction between LOX^high fibroblast and smooth muscle cells contributes to the pathogenesis of aortic dissection.

ABSTRACT: Rationale: While cell-cell interaction plays a critical role in physiology and disease, a comprehensive understanding of its dynamics in vascular homeostasis and diseases is yet absent. Methods: Here, by use of single-cell RNA-sequencing and multi-color staining, we delineate the cellular composition and spatial characterization of human aorta with or without aortic dissection (AD). Results: Scrutinization of cell subtype alterations revealed significantly changed fibroblast (FB)-smooth muscle cell (SMC) interactions in AD. Of these cellular interactions, LOX^high fibroblast (fibroblast subtype 2, FB2) in diseased state exerted the most pronounced effects on pathological deterioration of SMCs in AD. In addition, pharmacologically targeting the BMP (bone morph

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8692905 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature