Ontology highlight
ABSTRACT:
SUBMITTER: Vultaggio-Poma V
PROVIDER: S-EPMC8692914 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Vultaggio-Poma Valentina V Falzoni Simonetta S Chiozzi Paola P Sarti Alba Clara AC Adinolfi Elena E Giuliani Anna Lisa AL Sánchez-Melgar Alejandro A Boldrini Paola P Zanoni Michele M Tesei Anna A Pinton Paolo P Di Virgilio Francesco F
Theranostics 20220101 2
<b>Rationale</b>: Caloric restriction improves the efficacy of anti-cancer therapy. This effect is largely dependent on the increase of the extracellular ATP concentration in the tumor microenvironment (TME). Pathways for ATP release triggered by nutrient deprivation are largely unknown. <b>Methods:</b> The extracellular ATP (eATP) concentration was <i>in vivo</i> measured in the tumor microenvironment of B16F10-inoculated C57Bl/6 mice with the pmeLuc probe. Alternatively, the pmeLuc-TG-mouse wa ...[more]