Omadacycline Potentiates Clarithromycin Activity Against Mycobacterium abscessus.

ABSTRACT: Mycobacterium abscessus is a difficult respiratory pathogen to treat, when compared to other nontuberculus mycobacteria (NTM), due to its drug resistance. In this study, we aimed to find a new clarithromycin partner that potentiated strong, positive, synergy against M. abscessus among current anti-M. abscessus drugs, including omadacycline, amikacin, rifabutin, bedaquiline, and cefoxitine. First, we determined the minimum inhibitory concentrations required of all the drugs tested for M. abscessus subsp. abscessus CIP104536^T treatment using a resazurin microplate assay. Next, the best synergistic partner for clarithromycin against M. abscessus was determined using an in vitro checkerboard combination assay. Among the drug combinati

SUBMITTER: Bich Hanh BT 

PROVIDER: S-EPMC8693020 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature