Improved Protein Structure Prediction Using a New Multi-Scale Network and Homologous Templates.

ABSTRACT: The accuracy of de novo protein structure prediction has been improved considerably in recent years, mostly due to the introduction of deep learning techniques. In this work, trRosettaX, an improved version of trRosetta for protein structure prediction is presented. The major improvement over trRosetta consists of two folds. The first is the application of a new multi-scale network, i.e., Res2Net, for improved prediction of inter-residue geometries, including distance and orientations. The second is an attention-based module to exploit multiple homologous templates to increase the accuracy further. Compared with trRosetta, trRosettaX improves the contact precision by 6% and 8% on the free modeling targets of CASP13 and CASP14, respectively. A preliminary version of trRosettaX is ranked as

SUBMITTER: Su H 

PROVIDER: S-EPMC8693034 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature