Dataset Information

Biodegradable and Excretable 2D W_1.33 C i-MXene with Vacancy Ordering for Theory-Oriented Cancer Nanotheranostics in Near-Infrared Biowindow.

ABSTRACT: MXenes, a new class of two-dimensional (2D) nanomaterials, have shown enormous potential for biological applications. Notably, the development of 2D MXenes in nanomedicine is still in its infancy. Herein, a distinct W_1.33 C i-MXene with multiple theranostic functionalities, fast biodegradation, and satisfactory biocompatibility is explored. By designing a parent bulk laminate in-plane ordered (W_2/3 Y_1/3 )₂ AlC ceramic and optionally etching aluminum (Al) and yttrium (Y) elements, 2D W_1.33 C i-MXene nanosheets with ordered divacancies are efficiently fabricated. Especially, theoretical simulations reveal that W_1.33 C i-MXene possesses a strong predominance of near-infrared (NIR) absorbance. The constructed ultrathin W_1.33 C nanosheets feature excellent photothermal-conversion effectiveness (32.5% at NIR I and 49.3% at NIR II) with desirable biocompatibility and fast degradation in normal tissue rather than in tumor tissue. Importantly, the multimodal-imaging properties and photothermal-ablation performance of W_1.33 C-BSA nanosheets are systematically revealed and demonstrated both in vitro and in vivo. The underlying mechanism and regulation factors for the W_1.33 C-BSA nanosheets-induced hyperthermia ablation are also revealed by transcriptome and proteome sequencing. This work offers a paradigm that i-MXenes achieve the tailoring biomedical applications through composition and structure design on the atomic scale.

SUBMITTER: Zhou B

PROVIDER: S-EPMC8693041 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Biodegradable and Excretable 2D W1.33 C i-MXene with Vacancy Ordering for Theory-Oriented Cancer Nanotheranostics in Near-Infrared Biowindow.

Zhou Bangguo B Yin Haohao H Dong Caihong C Sun Liping L Feng Wei W Pu Yinying Y Han Xiaoxia X Li Xiaolong X Du Dou D Xu Huixiong H Chen Yu Y

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20211029 24

MXenes, a new class of two-dimensional (2D) nanomaterials, have shown enormous potential for biological applications. Notably, the development of 2D MXenes in nanomedicine is still in its infancy. Herein, a distinct W1.33 C i-MXene with multiple theranostic functionalities, fast biodegradation, and satisfactory biocompatibility is explored. By designing a parent bulk laminate in-plane ordered (W2/3 Y1/3 )2 AlC ceramic and optionally etching aluminum (A ...[more]

PMID: 34716674

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Project description:High valence multi transition metal hydroxides are greatly enriched with OER redox active sites due to strong synergy of heteroatomic nuclei. The efficiency of these redox active sites could be efficiently improved by coupling with highly conductive substrate. The advanced three-dimensional (3D) architecture and hydrophilic terminal functionalities of MXene (MX) considerably enhance the maximum utilization rate of anchored redox active sites by triggering the direct growth of these at MX substrate. Here-in, the freeze-dried 3D network of crumpled Vanadium-Carbide (V2C) MX sheets regulates the crystallization of in-situ grown NiFeCr multi transition metal hydroxides on MX scaffold through co-precipitation process. The XPS results suggest a synergistic chemical interaction of 3D MX scaffold with NiFeCr that modifies the electronic structure of the composite ensuring reduced charge transfer resistance. Besides, as found in FESEM morphological investigation, the well-dispersed NiFeCr multi-transition metal hydroxides are immobilized on open pores like structure of V2C-MX facilitate thoroughly accessible active sites. As a result, the NiFeCr@3D V2C-MX composite has shown an excellent electrocatalytic activity with an overpotential of 410 mV at a current density of 200 mA cm-2, Tafel slope of 100 mV dec in 1M KOH. Besides, the significant interaction between metallic centers and MXene support prevent detachment or agglomeration of active centers providing maximum interaction with the electrolytic ions, quick ionic OH- transportation, speedy and stable electron transfer channels thus ensure the long-term stability of NV-5MX during 53 h continuous operation of OER. Furthermore, we have utilized a more accurate value of half-cell standard reduction potential of the Hg/HgO electrode in the Nernst equation to represent all test voltages and to determine the overpotential values. In essence, this study features a facile approach for the confined growth of multi transition metal hydroxides in the presence of morphologically unique 3D crumpled V2C MXene architectures. Consequently, the increased OER reaction kinetics and improved stability of the synthesized composites are potentially due to synergistic interplay between well dispersed active sites and the conductive substrate.

Dataset Information

Biodegradable and Excretable 2D W_1.33 C i-MXene with Vacancy Ordering for Theory-Oriented Cancer Nanotheranostics in Near-Infrared Biowindow.

Publications

Biodegradable and Excretable 2D W<sub>1.33</sub> C i-MXene with Vacancy Ordering for Theory-Oriented Cancer Nanotheranostics in Near-Infrared Biowindow.

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