Vitamin D deficiency, impaired lung function and total and respiratory mortality in a cohort of older men: cross-sectional and prospective findings from The British Regional Heart Study.

ABSTRACT:

Objectives

Vitamin D deficiency is associated with chronic obstructive pulmonary disease (COPD). We examined the cross-sectional association between 25-hydroxyvitamin D (25(OH)D) and lung function impairment and assessed whether vitamin D deficiency is related to long-term mortality in those with impaired lung function.

Design

Prospective study SETTING: General practices in the UK.

Participants

3575 men aged 60-79 years with no prevalent heart failure.

Outcome measures

Airway obstruction and mortality. The Global Initiative on Obstructive Lung diseases (GOLD) spirometry criteria was used to define airway obstruction.

Results

During the follow-up period of 20 years, there were 2327 deaths (114 COPD deaths). Vitamin D deficiency was defined as serum 25(OH)

SUBMITTER: Wannamethee SG 

PROVIDER: S-EPMC8693094 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature