Genomic basis of evolutionary adaptation in a warm-blooded fish.

ABSTRACT: Few fishes have evolved elevated body temperatures compared with ambient temperatures, and only in opah (Lampris spp) is the entire body affected. To understand the molecular basis of endothermy, we analyzed the opah genome and identified 23 genes with convergent amino acid substitutions across fish, birds, and mammals, including slc8b1, which encodes the mitochondrial Na⁺/Ca²⁺ exchanger and is essential for heart function and metabolic heat production. Among endothermic fishes, 44 convergent genes with suggestive metabolic functions were identified, such as glrx3, encoding a crucial protein for hemoglobin maturation. Numerous genes involved in the production and retention of metabolic heat were also found to be under positive selection. Analyses

SUBMITTER: Wang X 

PROVIDER: S-EPMC8693259 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature