Lipoprotein particle alterations due to androgen therapy in individuals with dyskeratosis congenita.

ABSTRACT:

Background

Dyskeratosis congenita (DC) is a telomere biology disorder associated with high rates of bone marrow failure (BMF) and other medical complications. Oral androgens are successfully used to treat BMF in DC but often have significant side effects, including elevation of serum lipids. This study sought to determine the extent to which oral androgen therapy altered lipid and lipoprotein levels.

Methods

Nuclear magnetic resonance (NMR) was used to evaluate serum lipid profiles, and lipoprotein particle number and size in nine androgen-treated individuals with DC, 45 untreated individuals with DC, 72 unaffected relatives of DC patients, and 19 untreated individuals with a different inherited BMF syndrome, Fanconi anaemia (FA).

Findings

Androgen-treated individuals

SUBMITTER: Thompson MB 

PROVIDER: S-EPMC8693311 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature