Therapeutic efficacy of denosumab for rheumatoid arthritis: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Denosumab is used for osteoporosis because it inhibits osteoclast maturation and suppresses bone resorption. Although denosumab is expected to inhibit the bone erosion in RA, its therapeutic efficacy is not well established. The aim of this study was to estimate the effects of denosumab on RA through a meta-analysis.

Methods

A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. PubMed, Web of Science and Scopus were searched for original studies providing information on BMD, joint destruction and disease activity in denosumab-treated RA. A random-effects model was used in the meta-analysis.

Results

Of the 367 studies identified, 18 met the selection criteria. The BMDs of the lumbar spine

SUBMITTER: Yagita M 

PROVIDER: S-EPMC8693364 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature