Synthesis and in vivo evaluation of PEG-BP-BaYbF₅ nanoparticles for computed tomography imaging and their toxicity.

ABSTRACT: Computed tomography (CT) is one of the most widespread imaging techniques in clinical use worldwide. CT contrast agents are administered to improve soft tissue contrast and highlight blood vessels. However, the range of CT contrast agents available in the clinic is limited and they suffer from short-circulation times and low k-edge values that result in the need for high doses for in vivo applications. Nanomaterials containing a mixture of electron-dense elements, such as BaYbF₅ nanoparticles, have shown promise as more efficient CT contrast agents, but they require biocompatible coatings for biomedical applications. Here, we explore the use of a bifunctional PEG polymer (5 kDa) containing a terminal bisphosphonate (BP) anchor for efficient binding to the surface of BaYbF_5<

SUBMITTER: Imberti C 

PROVIDER: S-EPMC8693452 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature