Ontology highlight
ABSTRACT:
SUBMITTER: Gordon O
PROVIDER: S-EPMC8693472 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Gordon Oren O Lee Donald E DE Liu Bessie B Langevin Brooke B Ordonez Alvaro A AA Dikeman Dustin A DA Shafiq Babar B Thompson John M JM Sponseller Paul D PD Flavahan Kelly K Lodge Martin A MA Rowe Steven P SP Dannals Robert F RF Ruiz-Bedoya Camilo A CA Read Timothy D TD Peloquin Charles A CA Archer Nathan K NK Miller Lloyd S LS Davis Kimberly M KM Gobburu Jogarao V S JVS Jain Sanjay K SK
Science translational medicine 20211201 622
<i>Staphylococcus aureus</i> is a major human pathogen causing serious implant–associated infections. Combination treatment with rifampin (10 to 15 mg/kg per day), which has dose-dependent activity, is recommended to treat <i>S. aureus</i> orthopedic implant–associated infections. Rifampin, however, has limited bone penetration. Here, dynamic <sup>11</sup>C-rifampin positron emission tomography (PET) performed in prospectively enrolled patients with confirmed <i>S. aureus</i> bone infection (<i> ...[more]