Analysis of sex-based differences in clinical and molecular responses to ischemia reperfusion after lung transplantation.

ABSTRACT:

Background

Sex and hormones influence immune responses to ischemia reperfusion (IR) and could, therefore, cause sex-related differences in lung transplantation (LTx) outcomes. We compared men's and women's clinical and molecular responses to post-LTx IR.

Methods

In 203 LTx patients, we used the 2016 International Society for Heart and Lung Transplantation guidelines to score primary graft dysfunction (PGD). In a subgroup of 40 patients with blood samples collected before LTx (T0) and 6, 24, 48 (T48), and 72 h (T72) after lung reperfusion, molecular response to IR was examined through serial analysis of circulating cytokine expression.

Results

After adjustment, women had less grade 3 PGD than men at T48, but not at T72. PGD grade decreased from T0 to T72 more often in

SUBMITTER: Chacon-Alberty L 

PROVIDER: S-EPMC8693497 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature