Assessment of children in the autistic spectrum disorder that carry the Thr92Ala-DIO2 polymorphism.

ABSTRACT:

Introduction

A polymorphism in the type 2 deiodinase (Thr92Ala-DIO2) gene has been associated with behavioral and cognitive dysfunction as well as neurodegeneration and oxidative stress in the central nervous system.

Objective

To test whether the minor allele (Ala92) frequency (MAF) is increased in children in the autism spectrum disorder (ASD), and whether carriers of the minor allele exhibit more severe symptoms and/or worse adaptive behavior.

Study design

ASD children were evaluated at baseline and yearly throughout the study by psychologists using the following tools: autism behavior checklist, Vineland Adaptative Behaviour Scales II, non-verbal intelligence test SON-R 2^1/2-7, SON-R 6-40, Weschler scale for intelligence, and autism treatment evaluation

SUBMITTER: E Marcondes AA 

PROVIDER: S-EPMC8693502 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature